Retinoid X receptors

カタログ番号	製品名	別名	ターゲット
T22843	HX 531		Retinoid Receptor
	RXR antagonist		Retinoid Receptor
T17209	UVI 3003		Retinoid Receptor , Autophagy
	UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respectively).		Retinoid Receptor , Autophagy
TQ0097	AGN 193109		Retinoid Receptor , Autophagy
	AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).		Retinoid Receptor , Autophagy
T5341	WYC-209	WYC209	Apoptosis , Retinoid Receptor , Autophagy
	WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).		Apoptosis , Retinoid Receptor , Autophagy
T3955	AR7		Retinoid Receptor
	AR7 is a retinoic acid receptor α (RARα) antagonist.		Retinoid Receptor
T1093	Adapalene	CD271	Apoptosis , Retinoid Receptor , Autophagy
	Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.		Apoptosis , Retinoid Receptor , Autophagy
T7370	Talarozole	R115866	Others , P450 , Retinoid Receptor , Autophagy
	Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of...		Others , P450 , Retinoid Receptor , Autophagy
T7586	Trifarotene	CD5789	Retinoid Receptor , Autophagy
	Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).		Retinoid Receptor , Autophagy
T21714	BMS453	BMS 453,BMS-189453	Retinoid Receptor
	BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.		Retinoid Receptor
TQ0064	Peretinoin	NIK333	HCV Protease , Retinoid Receptor , S1P Receptor , Autophagy
	Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
T6696	Tazarotene	Tazorac,AGN 190168,Zorac	Retinoid Receptor , Autophagy
	Tazarotene (Zorac) is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiati...		Retinoid Receptor , Autophagy
T23383	SR11237	SR 11237	Others , RAR/RXR
	SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.		Others , RAR/RXR
T4538	Palovarotene	Ro 3300074,R 667	Retinoid Receptor , Autophagy
	Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).		Retinoid Receptor , Autophagy
T6410	Bexarotene	Ro 26-4455,Targretin,LGD1069	Retinoid Receptor , Autophagy
	Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).		Retinoid Receptor , Autophagy
T11844	LG-100064		Retinoid Receptor , Autophagy
	LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)		Retinoid Receptor , Autophagy
T1872	Fenretinide	4-HPR,MK-4016,4-hydroxy(phenyl)retinamide	Retinoid Receptor , Autophagy
	Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.		Retinoid Receptor , Autophagy
T21314	Amsilarotene	TAC-101,TAC 101,TAC101	CDK
	Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cy...		CDK
T6694	Tamibarotene	NSC 608000,Am 80,Amnolake	Apoptosis , Retinoid Receptor , Autophagy
	Tamibarotene (Amnolake) is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity.		Apoptosis , Retinoid Receptor , Autophagy
T5843	Tarenflurbil	MPC7869,(R)-Flurbiprofen,R-flurbiprofen	Retinoid Receptor , Autophagy
	Tarenflurbil ((R)-Flurbiprofen) is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease.		Retinoid Receptor , Autophagy
T11847L	Liarozole	R75251 dihydrochloride	P450 , Retinoid Receptor
	Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1...		P450 , Retinoid Receptor
T5854	AM580	NSC608001,CD336,Ro 40-6055	Retinoid Receptor , Autophagy
	AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )		Retinoid Receptor , Autophagy
T4371	CD437	AHPN,O-Desmethyl Adapalene,Apoptosis Activator VI	Retinoid Receptor , Autophagy
	CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist.		Retinoid Receptor , Autophagy
T1288	TTNPB	AGN191183,Arotinoid acid,Ro 13-7410,AGN-191183,Ro 13-7410	Apoptosis , Retinoid Receptor , Autophagy
	TTNPB (Ro 13-7410,AGN-191183), a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively.		Apoptosis , Retinoid Receptor , Autophagy
T0499	Oxybenzone	KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,Escalol 567	Apoptosis , Retinoid Receptor , Autophagy
	Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone.		Apoptosis , Retinoid Receptor , Autophagy
T15811	LY2955303		Others , Retinoid Receptor
	LY2955303 is an effective and selective retinoic acid receptor gamma (RARγ) antagonist (Ki: 1.09 nM).		Others , Retinoid Receptor
T70165	V-125
	V-125 is an agonist of retinoid X receptors.
T19703	LG100268	LG 100268,LG-100268
	LG100268 is an effective and selective rexinoid and retinoid-X receptor agonist. LG100268 binds to the α, β, and γ RXR receptors (IC50 = 3-4 nM).
T37414	CAY10771
	CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively)...

Compounds

HX 531

T22843

Synonym:

Target: Retinoid Receptor

UVI 3003

T17209

Synonym:

Target: Retinoid Receptor, Autophagy

AGN 193109

TQ0097

Synonym:

Target: Retinoid Receptor, Autophagy

WYC-209

T5341

Synonym: WYC209

Target: Apoptosis, Retinoid Receptor, Autophagy

AR7

T3955

Synonym:

Target: Retinoid Receptor

Adapalene

T1093

Synonym: CD271

Target: Apoptosis, Retinoid Receptor, Autophagy

Talarozole

T7370

Synonym: R115866

Target: Others, P450, Retinoid Receptor, Autophagy

trifarotene

T7586

Synonym: CD5789

Target: Retinoid Receptor, Autophagy

BMS453

T21714

Synonym: BMS 453,BMS-189453

Target: Retinoid Receptor

Peretinoin

TQ0064

Synonym: NIK333

Target: HCV Protease, Retinoid Receptor, S1P Receptor, Autophagy

Tazarotene

T6696

Synonym: Tazorac,AGN 190168,Zorac

Target: Retinoid Receptor, Autophagy

SR11237

T23383

Synonym: SR 11237

Target: Others, RAR/RXR

palovarotene

T4538

Synonym: Ro 3300074,R 667

Target: Retinoid Receptor, Autophagy

Bexarotene

T6410

Synonym: Ro 26-4455,Targretin,LGD1069

Target: Retinoid Receptor, Autophagy

LG-100064

T11844

Synonym:

Target: Retinoid Receptor, Autophagy

Fenretinide

T1872

Synonym: 4-HPR,MK-4016,4-hydroxy(phenyl)retinamide

Target: Retinoid Receptor, Autophagy

Amsilarotene

T21314

Synonym: TAC-101,TAC 101,TAC101

Target: CDK

Tamibarotene

T6694

Synonym: NSC 608000,Am 80,Amnolake

Target: Apoptosis, Retinoid Receptor, Autophagy

Tarenflurbil

T5843

Synonym: MPC7869,(R)-Flurbiprofen,R-flurbiprofen

Target: Retinoid Receptor, Autophagy

Liarozole

T11847L

Synonym: R75251 dihydrochloride

Target: P450, Retinoid Receptor

AM580

T5854

Synonym: NSC608001,CD336,Ro 40-6055

Target: Retinoid Receptor, Autophagy

CD437

T4371

Synonym: AHPN,O-Desmethyl Adapalene,Apoptosis Activator VI

Target: Retinoid Receptor, Autophagy

TTNPB

T1288

Synonym: AGN191183,Arotinoid acid,Ro 13-7410,AGN-191183,Ro 13-7410

Target: Apoptosis, Retinoid Receptor, Autophagy

Oxybenzone

T0499

Synonym: KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,Escalol 567

Target: Apoptosis, Retinoid Receptor, Autophagy

LY2955303

T15811

Synonym:

Target: Others, Retinoid Receptor

Synonym: LG 100268,LG-100268

カタログ番号	製品名	別名	ターゲット
TN6735	Bigelovin		Apoptosis , Reactive Oxygen Species , Retinoid Receptor , Autophagy , RAR/RXR
	Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a pote...
T1330	Acitretin	Ro 10-1670,Etretin	Apoptosis , Retinoid Receptor , Autophagy
	Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.		Apoptosis , Retinoid Receptor , Autophagy
T1051	Retinoic acid	Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin	Retinoid Receptor , Endogenous Metabolite , PPAR , Autophagy
	Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferat...
T3000	Magnolol	NSC 293099,5,5'-Diallyl-2,2'-biphenyldiol	NF-κB , Retinoid Receptor , Antibacterial , PPAR , p53 , Autophagy
	Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
T1611	Isotretinoin	13-cis-Retinoic acid	Retinoid Receptor , Endogenous Metabolite , Autophagy
	Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretinoin is a naturall...		Retinoid Receptor , Endogenous Metabolite , Autophagy